[摘要] [目的] 探讨决明子乙醇提取物对D-氨基半乳糖所致大鼠急性肝损伤的保护作用. [方法] 灌胃给予给药组大鼠10，5g/kg决明子乙醇提取物，阳性对照组大鼠给予0.2g/kg联苯双酯，正常对照组及模型对照组大鼠给予等体积生理盐水，连续5d.实验第4日给予模型对照组和给药组大鼠腹腔注射0.5g/kg D-氨基半乳糖，给予正常对照组大鼠腹腔注射等体积生理盐水.24h后摘眼球取血，剖取肝组织，制备肝线粒体悬浮液，分别测定血清ALT，AST，SOD，GSH-PX活性及MDA含量，测定肝线粒体SOD，GSH-PX活性及MDA含量. [结果] 决明子乙醇提取物可显著抑制D-氨基半乳糖所致急性肝损伤大鼠血清中ALT，AST质量浓度的升高，并提高血清及肝线粒体SOD，GSH-PX活性，降低MDA含量. [结论] 决明子乙醇提取物对D-氨基半乳糖所致大鼠急性肝损伤具有保护作用.

    [关键词] 肝衰竭，急性;植物，药用;大鼠

    Protective effects of Semen Cassiae aqueous extract on acute hepatic injury in rats

    CUI Xiang-yu

    (Department of Pharmaceutics，Affiliated Hospital of Yanbian University，Yanji133000，Jilin，China)

    ABSTRACT:OBJECTIVE To study the protective effects of Semen Cassiae aqueous extract on acute hepatic injury induced by D-galactoasmine in rats.METHODS The rats in administration groups ......